解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-CLIP, RIP-chip, and...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.06.007
更新日期:2011-08-05 00:00:00
abstract::The RNA-binding protein HuR, while known to stabilize cytoplasmic mRNAs, is largely nuclear. In this issue of Molecular Cell, Mukherjee et al. (2011) and Lebedeva et al. (2011) identify transcriptome-wide HuR-RNA interactions using PAR-CLIP, unveiling HuR's nuclear role in pre-mRNA processing. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2011.07.016
更新日期:2011-08-05 00:00:00
abstract::Bacterial actin MreB is one of the key components of the bacterial cytoskeleton. It assembles into short filaments that lie just underneath the membrane and organize the cell wall synthesis machinery. Here we show that MreB from both T. maritima and E. coli binds directly to cell membranes. This function is essential ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.07.008
更新日期:2011-08-05 00:00:00
abstract::Dysregulation of Wnt signaling has been implicated in tumorigenesis. The role of Transducin β-like proteins TBL1-TBLR1 in the promotion of Wnt/β-catenin-mediated oncogenesis has recently been emphasized; however, the molecular basis of activation of Wnt signaling by the corepressor TBL1-TBLR1 is incompletely understoo...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.05.027
更新日期:2011-07-22 00:00:00
abstract::The RNA-binding protein Sam68 is implicated in various cellular processes including RNA metabolism, apoptosis, and signal transduction. Here we identify a role of Sam68 in TNF-induced NF-κB activation and apoptosis. We found that Sam68 is recruited to the TNF receptor, and its deficiency dramatically reduces RIP recru...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.05.007
更新日期:2011-07-22 00:00:00
abstract::Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage targets are poorly understood. Caspase-2 is activated by the p53 target gene product PIDD (also known as LRDD) in a complex called the Caspase-2-PIDDosome. We show that PIDD expression promotes growth arrest and chemotherapy res...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.06.012
更新日期:2011-07-08 00:00:00
abstract::Autophagy, a catabolic pathway that delivers cellular components to lysosomes for degradation, can be activated by stressful conditions such as nutrient starvation and endoplasmic reticulum (ER) stress. We report that thapsigargin, an ER stressor widely used to induce autophagy, in fact blocks autophagy. Thapsigargin ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.04.024
更新日期:2011-06-24 00:00:00
abstract::Activation of p53 by DNA damage results in either cell-cycle arrest, allowing DNA repair and cell survival, or induction of apoptosis. As these opposite outcomes are both mediated by p53 stabilization, additional mechanisms to determine this decision must exist. Here, we show that glycogen synthase kinase-3 (GSK-3) is...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.03.033
更新日期:2011-06-10 00:00:00
abstract::We have identified human MBT domain-containing protein L3MBTL2 as an integral component of a protein complex that we termed Polycomb repressive complex 1 (PRC1)-like 4 (PRC1L4), given the copresence of PcG proteins RING1, RING2, and PCGF6/MBLR. PRC1L4 also contained E2F6 and CBX3/HP1γ, known to function in transcripti...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.04.004
更新日期:2011-05-20 00:00:00
abstract::The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2 is modulated by histone modifications associated with transcriptionally active chromatin. We provide the molecular basis of histone H3 N terminus recognition by...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.03.025
更新日期:2011-05-06 00:00:00
abstract::It has been suspected that cell-cycle progression might be functionally coupled with RNA processing. However, little is known about the role of the precise splicing control in cell-cycle progression. Here, we report that SON, a large Ser/Arg (SR)-related protein, is a splicing cofactor contributing to efficient splici...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.03.014
更新日期:2011-04-22 00:00:00
abstract::Adrenergic stimulation of the heart engages cAMP and phosphoinositide second messenger signaling cascades. Cardiac phosphoinositide 3-kinase p110γ participates in these processes by sustaining β-adrenergic receptor internalization through its catalytic function and by controlling phosphodiesterase 3B (PDE3B) activity ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.01.030
更新日期:2011-04-08 00:00:00
abstract::Rapid recognition and signal transduction of mechanical wounding through various signaling molecules, including calcium (Ca²+), protein phosphorylation, and reactive oxygen species (ROS), are necessary early events leading to stress resistance in plants. Here we report that an Arabidopsis mitogen-activated protein kin...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.02.029
更新日期:2011-03-18 00:00:00
abstract::Eukaryotic cells license far more origins than are actually used for DNA replication, thereby generating a large number of dormant origins. Accumulating evidence suggests that such origins play a role in chromosome stability and tumor suppression, though the underlying mechanism is largely unknown. Here, we show that ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.02.006
更新日期:2011-03-04 00:00:00
abstract::Transcript-selective translational regulation of epithelial-mesenchymal transition (EMT) by transforming growth factor-β (TGF-β) is directed by the hnRNP E1-containing TGF-β-activated-translational (BAT) mRNP complex. Herein, eukaryotic elongation factor-1 A1 (eEF1A1) is identified as an integral component of the BAT ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.02.003
更新日期:2011-02-18 00:00:00
abstract::Gene expression mediated by viral vectors is subject to cell-to-cell variability, which limits the accuracy of gene delivery. When coupled with single-cell measurements, however, such variability provides an efficient means to quantify signaling dynamics in mammalian cells. Here, we illustrate the utility of this appr...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.01.014
更新日期:2011-02-04 00:00:00
abstract::Expression of BRCA1 is commonly decreased in sporadic breast tumors, and this correlates with poor prognosis of breast cancer patients. Here we show that BRCA1 transcripts are selectively enriched in the Argonaute/miR-182 complex and miR-182 downregulates BRCA1 expression. Antagonizing miR-182 enhances BRCA1 protein l...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.12.005
更新日期:2011-01-21 00:00:00
abstract::In eukaryotes, a crucial step of translation initiation is the binding of the multifactor complex eIF4F to the 5' end of the mRNA, a prerequisite to recruitment of the activated small ribosomal 43S particle. Histone H4 mRNAs have short 5'UTRs, which do not conform to the conventional scanning-initiation model. Here we...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.12.019
更新日期:2011-01-21 00:00:00
abstract::Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II transcripts. We now show that Sen1 helicase possesses a wider function by restricting the occurrence of RNA:DNA hybrids that may naturally form dur...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.12.007
更新日期:2011-01-07 00:00:00
abstract::The dynamic protein interactions required for transcription are functionally important yet poorly understood; in this issue of Molecular Cell, Zobeck et al. (2010) resolve the sequential recruitment and selective recycling of transcription factors at an actively transcribing locus in Drosophila. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.12.010
更新日期:2010-12-22 00:00:00
abstract::Multisubunit protein complexes pose a challenge to the coordinated regulation of individual components. We show how the yeast transactivating factor Met4 functions as a component of the SCF(Met30) ubiquitin ligase to synchronize its own activity with cofactor assembly. Cells maintain Met4 in a dormant state by a regul...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.11.018
更新日期:2010-12-22 00:00:00
abstract::The accurate propagation of histone marks during chromosomal replication is proposed to rely on the tight coupling of replication with the recycling of parental histones to the daughter strands. Here, we show in the avian cell line DT40 that REV1, a key regulator of DNA translesion synthesis at the replication fork, i...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.11.009
更新日期:2010-12-10 00:00:00
abstract::The duplication of eukaryotic genomes involves the replication of DNA from multiple origins of replication. In S phase, two sister replisomes assemble at each active origin, and they replicate DNA in opposite directions. Little is known about the functional relationship between sister replisomes. Some data imply that ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.11.027
更新日期:2010-12-10 00:00:00
abstract::Eukaryotic transcription and mRNA processing depend upon the coordinated interactions of many proteins, including Spn1 and Spt6, which are conserved across eukaryotes, are essential for viability, and associate with each other in some of their biologically important contexts. Here we report crystal structures of the S...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.11.014
更新日期:2010-12-10 00:00:00
abstract::Checkpoint proteins respond to DNA damage by halting the cell cycle until the damage is repaired. In this issue of Molecular Cell, Furuya et al. (2010) provide evidence that checkpoint proteins need to be removed from sites of damage in order to properly repair it. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.11.015
更新日期:2010-11-24 00:00:00
abstract::When inappropriate DNA structures arise, they are sensed by DNA structure-dependent checkpoint pathways and subsequently repaired. Recruitment of checkpoint proteins to such structures precedes recruitment of proteins involved in DNA metabolism. Thus, checkpoints can regulate DNA metabolism. We show that fission yeast...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.10.026
更新日期:2010-11-24 00:00:00
abstract::The histone methyltransferase PR-Set7/Set8 is the sole enzyme that catalyzes monomethylation of histone H4 at K20 (H4K20me1). Previous reports document disparate evidence regarding PR-Set7 expression during the cell cycle, the biological relevance of PR-Set7 interaction with PCNA, and its role in the cell. We find tha...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.10.011
更新日期:2010-11-12 00:00:00
abstract::In this issue of Molecular Cell, Savir and Tlusty (2010) apply signal detection theory to show that homologous recombination machinery is optimally tuned to find homologous DNA sequences within an exceptionally high background of heterologous sequences. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.10.032
更新日期:2010-11-12 00:00:00
abstract::Cse4 is a variant of histone H3 that is incorporated into a single nucleosome at each centromere in budding yeast. We have discovered an E3 ubiquitin ligase, called Psh1, which controls the cellular level of Cse4 via ubiquitylation and proteolysis. The activity of Psh1 is dependent on both its RING and zinc finger dom...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.10.014
更新日期:2010-11-12 00:00:00
abstract::Organisms must survive a variety of stressful conditions, including sudden temperature increases that damage important cellular structures and interfere with essential functions. In response to heat stress, cells activate an ancient signaling pathway leading to the transient expression of heat shock or heat stress pro...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2010.10.006
更新日期:2010-10-22 00:00:00
abstract::The membrane-spanning C-terminal regions in tail-anchored proteins must be recognized and delivered posttranslationally to the endoplasmic reticulum or mitochondrial membrane. A paper in this issue of Molecular Cell (Wang et al., 2010) and another recent report (Mariappan et al., 2010) delineate early steps in this pa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.09.016
更新日期:2010-10-08 00:00:00
abstract::Signal-induced alternative splicing of the CD45 gene in human T cells is essential for proper immune function. Skipping of the CD45 variable exons is controlled, in large part, by the recruitment of PSF to the pre-mRNA substrate upon T cell activation; however, the signaling cascade leading to exon exclusion has remai...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.09.013
更新日期:2010-10-08 00:00:00
abstract::In this issue of Molecular Cell, Tripathi and coworkers (Tripathi et al., 2010) decode some of the functions of a long noncoding RNA MALAT1. They provide evidence that MALAT1 regulates alternative splicing by controlling the activity of the SR protein family of splicing factors. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.09.003
更新日期:2010-09-24 00:00:00
abstract::Translational control is frequently exerted at the stage of mRNA recruitment to the initiating ribosome. We have reconstituted mRNA recruitment to the 43S preinitiation complex (PIC) using purified S. cerevisiae components. We show that eIF3 and the eIF4 factors not only stabilize binding of mRNA to the PIC, they also...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.08.021
更新日期:2010-09-24 00:00:00
abstract::Cohesion between sister chromatids is mediated by the chromosomal cohesin complex. In budding yeast, cohesin is loaded onto chromosomes during the G1 phase of the cell cycle. During S phase, the replication fork-associated acetyltransferase Eco1 acetylates the cohesin subunit Smc3 to promote the establishment of siste...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.08.009
更新日期:2010-09-10 00:00:00
abstract::The Rictor/mTOR complex (also known as mTORC2) plays a critical role in cellular homeostasis by phosphorylating AGC kinases such as Akt and SGK at their hydrophobic motifs to activate downstream signaling. However, the regulation of mTORC2 and whether it has additional function(s) remain largely unknown. Here, we repo...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.08.016
更新日期:2010-09-10 00:00:00
abstract::Chaperone-mediated autophagy (CMA) is involved in cellular quality control, and in the response to stress, deterioration in CMA contributes to the aging phenotype and to various disorders. The paper by Bandyopadhyay et al. in this issue of Molecular Cell demonstrates the role of GTP binding by elongation factor 1 alph...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2010.08.005
更新日期:2010-08-27 00:00:00
abstract::The eukaryotic RNA polymerases Pol I, II, and III use different promoters to transcribe different classes of genes. Promoter usage relies on initiation factors, including TFIIF and TFIIE, in the case of Pol II. Here, we show that the Pol I-specific subunits A49 and A34.5 form a subcomplex that binds DNA and is related...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.07.028
更新日期:2010-08-27 00:00:00
abstract::The signal transducers of the transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP), the Smads, promote the expression of a subset of miRNAs by facilitating the cleavage reaction by Drosha. The mechanism that limits Smad-mediated processing to a selective group of miRNAs remained hitherto unexplor...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.07.011
更新日期:2010-08-13 00:00:00
abstract::Polyubiquitination is a posttranslational modification where ubiquitin chains containing isopeptide bonds linking one of seven ubiquitin lysines with the C terminus of an adjoining ubiquitin are covalently attached to proteins. While functions of K48- and K63-linked polyubiquitin are understood, the role(s) of noncano...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.07.001
更新日期:2010-08-13 00:00:00